 This study examined the interactions between tumors and their environment, focusing specifically on the role of specialized cells called skin cancer associated macrophages, scams. It was discovered that these cells are present in high numbers around tumors and play a key role in supporting tumor growth. Additionally, it was found that scams can be induced from circulating monocytes and can self-propagate within the tumor environment. These results suggest that targeting scams may provide a new therapeutic approach for treating cancer. This article was authored by Daniel Hensel, Benz Daniel, Sodnogadum, and others.