 A drug's aqueous solubility is defined as its ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. Up to 40% of commercialized products and 70-90% of drug candidates in the development stage are poorly soluble, resulting in low bioavailability, diminished therapeutic effects, and dosage escalation. Due to this, solubility must be considered when developing and fabricating pharmaceutical products. Several approaches have been investigated to address the problem of poor solubility, including physical and chemical methods such as particle size reduction, solid dispersion, supercritical fluid technology, cryogenic technology, inclusion complex formation, floating granules, and structural modifications like pro-drugs, salts, co-crystals, co-solvents, hydrotropy, polymorphs, amorphous solid dispersions, and pH variation. Additionally, nanotechnology has been used to improve solubility, including liposomes, nanoparticles, dendrimers, micelles, metal organic frameworks, nanogels. This article was authored by Lakshmi Kumari, Yash Jodari, Preeti Patel, and others. We are article.tv, links in the description below.