 Solid lipid nanoparticles, acylins, and nanostructured lipid carriers, NLCS, are two popular lipid-based drug delivery systems that have gained attention in recent years due to their ease of manufacture, scale-up capabilities, biocompatibility, and biodegradability. These systems can be used for various routes of administration, including oral, nasal, ocular, pulmonary, and parenteral. They offer several advantages over traditional formulations, such as improved solubility, enhanced stability, and increased bioavailability. However, there are certain limitations associated with acylins and NLCS, such as difficulty in achieving high encapsulation efficiency, low loading capacity, and potential toxicity. Despite these drawbacks, both acylins and NLCS remain attractive options for drug delivery due to their versatility and potential to improve patient outcomes. This article was authored by Parisa Ghasenye and Solomon Moham Desamani. We are article.tv. Links in the description below.