 The study investigates the association between gastric cancer with cookstove use, H. pylori-cage infection and genetic variants that metabolize and affect carcinogen internal dose in a population-based case control study in rural Honduras. Male sex, age, would cookstove use, cage sarastatus, and two SNPs in CYP1B1 were independently associated with gastric cancer in multivariate analysis. An important gene-environment interaction was noted between wood-cookstove use and the RS1800440 metabolizing genotype. Lifetime wood-cookstove use associates with gastric cancer risk in high-incidence regions of Central America and the association is dependent on the RS1800440 genotype in CYP1B1. H. pylori-cage infection would cookstove use and the RS1800440 genotype inform who is at greatest risk from biomass cookstove use. This article was authored by Samara B. Rifkin, Anna K. Miller, Eliezer E. Montalvan Sanchez, and others. We are article.tv, links in the description below.