 The bitter-taste receptor TAS2R4 has been found to be structurally different from other class AGPCRs, which suggests a unique activation mechanism and a less stable inactive state. The structure of this receptor was determined using the GENC-MBLE complete sampling method, which revealed a unique coupling between the G protein and the receptor, allowing for better understanding of how the receptor works and how it can be targeted for drug development. This article was authored by Moon Young-Young, Amir Hussain-Marfi, Sikyung Kim, and others.