 Oyster mushrooms, pleurotus austridis, are nutritious and medicinal mushrooms with unique properties that make them valuable for an atherosclerosis diet. Their fruit bodies contain proteins, carbohydrates, fatty acids, vitamins, and minerals, while their high fiber content and low fat make them beneficial for digestive health and lowering cholesterol and triglyceride levels. The mushrooms are also rich in biologically active substances such as polysaccharides and polyphenol that have antioxidant, antibacterial, antiviral, antidiabetic, and anti-inflammatory properties. Numerous scientific studies have shown the high efficiency of oyster mushroom therapy for prophylaxis and cure of civilization diseases, atherosclerosis, and cancer. This article was authored by Andre Salata, Marta Lemisek, and Marzena Parzomis.