 Hello everyone welcome back to a new session on dentistry and more Today we have two genetic disorders that is down syndrome and garland got syndrome Down syndrome is also known as trisomy 21 and garland got syndrome. It is a autosomal dominant Syndrome which is having a tried off Classic symptoms. Now, let's see what are these two? disorders So down syndrome it is a chromosomal abnormality Where the problem lies with the chromosome number 21? So it is known as trisomy 21 an extra chromosome is present on 21 So it is clinically presented as Flattened face, there'll be small head short neck protruding tongue and Upward palpibril fissure with small ear and there'll be poor muscle torn and broad and short hands short fingers and excessive Flexibility there are lots of clinical presentation, but I have mentioned a very few So the problem with the chromosome number 21 With flattened face small head short neck protruding tongue upward palpibril fissure small ear poor muscle torn broad and short hands short fingers and excessive Flexibility so what are the Risk factors the most common risk factor one is anyway, it is a genetical involvement. So there is genetic problems and the family ill tendency might be there and another one is a Advanced maternal age as the age of Mother increases the chances of Down syndrome also increases and These Down syndrome kids or persons will be having problems with heart and Gastrointestinal defect will be there. There'll be immune disorders They might facing sleep apnea obesity and spinal Problems so these are kind of multi system involvement and On a treatment side, there is not much treatment only just to improve the quality of life and Provide a good social support But when we think about the dental aspect Since the patient is having high production of saliva the chances of carous is very less but the patient or the person might not be able to Do a proper oral hygiene measures? So in turn the gingeritis and periodontal problems will be very high and there will be increased Braxism and Hypertonic tongue and mouth breathing will be there That persons will be with narrow palate and class 3 Prognetic profile so Down syndrome is a multi system Involvement due to the trisomy 21 So now let's move on to the garland God syndrome garland God syndrome It's also known as Nevoid-Pacel-Cel-Casinoma syndrome As a name suggests it was Explained by two people that is garland and God's it is also a genetical problem that is autosomal dominant genetical disorders and The involved gene is PTCH1 gene So that is a gene involved in this particular syndrome and it is expressed as a classical triad that is multiple basal cellular epithelioma that is a malignant condition and The keratosis there will be many keratosis oral keratosis and bifid ribs So this is a classical triad symptoms of garland God syndrome Basal cell-Casinoma, Ocaseas and bifid ribs So there are many other problems other clinical problems Involved with this garland God syndrome and the first one is the calcification of Fox cerebri The parmar, plantar, epidermal pits, the spine, rib, abnormalities macrosaphalae, frontal bosing and ocular malformation So this will be most commonly diagnosed by major criteria and minor criteria Major criteria the presence of more than two basal cell-Casinoma under 20 years and Ocaseas that is autosomal keratosis presence and Parmar pits If more than three and also the bifid ribs, these are the major criteria, but as a minor criteria is microcephaly, sorry the macrocephaly Then the hypertylerism and frontal bosing So these are the minor criteria to diagnose the garland God syndrome or just known as the God syndrome so treatment is basically the inoculation of all the cysts, Ocaseas and Genetic counseling also can be done as a preventive measure So these are two genetic disorders that is Down syndrome and garland God syndrome. These are commonly asked question So we can write all the clinical features the course and Some of the risk factors and the diagnosis criteria and related to the dental problem In case of Down syndrome, I'll come up with new syndromes and then just turn more. Thank you