 The P53 gene is a tumor suppressor gene that plays a critical role in preventing cancer. It can be activated when cells experience stress, such as exposure to radiation or chemicals, and it regulates many processes within the cell, including cell division, DNA repair, metabolism, angiogenesis, apoptosis, and more. There are several types of P53 proteins, each with unique functions. These proteins are modified through fast-relation and acetylation, which affect their activity levels. Additionally, P53 can also be degraded through ubiquitin-mediated proteolysis. When P53 is abnormally activated, it can cause cancer. Targeted therapies for P53 signaling are currently being developed, but they are still in the early stages of testing. One drug, TiP1, targets the mitochondria-dependent apoptosis pathway, which could potentially be used to treat certain types of cancer. This article was authored by Jin Shen, Quiruan, Yunan Mao, and others. We are article.tv, links in the description below.