 The objective of this review was to determine whether using the patient, intervention, comparison, outcome, PICO, model as a search strategy tool affected the quality of a literature search. Methods, a comprehensive literature search was conducted in PubMed, M-Base, SINL, PSYC Info, Cochrane Library, Web of Science, Library and Information Science Abstracts, LISA, SCOPIS, and the National Library of Medicine, NLM, catalog up until January 9, 2017. Reference lists were scrutinized and citation searches were performed on the included studies. The primary outcome was the quality of literature searches and the secondary outcome was the amount of time spent on the literature search when the PICO model was used as a search strategy tool compared to the use of another conceptualization tool or unguided searching. Results, a total of 2,163 records were identified and after removal of duplicates and initial screening, 22 full text articles were assessed. Of these, 19 studies were excluded and 3 studies were included, data was extracted, risk of bias was assessed, and A. This article was authored by MetaBrand Ericsson and Toe Faber-Francen. We are article.tv, links in the description below.