 Our study aimed to estimate the prevalence of surgical site infections, SSIS, following open reduction and internal fixation, ORIF, for mandibular fractures and to investigate the effect of potential moderators on it. We found that the overall prevalence of SSIS following ORIF for mandibular fractures was estimated at 4.2%, with significant heterogeneity between studies. One study was identified to be critical influential. In the subgroup analysis, the prevalence was 4.2% in Europe, 4.3% in Asia, and 7.3% in America. These findings suggest that further research is needed to better understand the etiology of these infections, despite their relatively low incidence. This article was authored by Von Elos Coasters, Georgia Coaster, Michael Coasters, and others.