 This paper discusses a novel technique for treating post-amputation pain in patients who have undergone a major lower extremity amputation. The authors describe their institution's approach which involves targeted muscle re-innovation, TMR, a procedure that uses a patient's own muscles to provide sensory feedback to the brain. Additionally, they detail how this technique differs from other approaches, including those involving transfers of multiple nerves. This article was authored by Brian L. Chong, MD, and Grant M. Kleiber, MD.