 The decline of organismal functions during abstract aging is accompanied by a series of prominent hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic changes include DNA methylation, histone modification, chromatin remodeling, non-coding RNA, NCRNA, regulation, and RNA modification, all of which participate in the regulation of the aging process and contribute to aging-related diseases. Understanding the epigenetic mechanisms in aging will provide new avenues to develop strategies to delay aging, such as small molecule-based therapies and reprogramming strategies that enable epigenetic rejuvenation. Adopting health-promoting activities, such as caloric restriction, exercise, and calibrating circadian rhythm, has also been demonstrated to delay aging. Clinical trials for aging intervention are ongoing, providing more evidence of the safety and efficacy of these therapies. A better understanding of the critical roles of epigenetics in the aging process will lead to more clinical advances in the prevention of human aging and therapy of aging-related diseases. This article was authored by Kang Wang, who had sewn you, Qin Chaohu, and others. We are article.tv, links in the description below.