 6. Hydroxy-Dopamine, 6 OHDA, was used to induce Parkinson's disease in rats, and sodium hydrogen sulfide, SHS, was used as a H2S donor to test the hypothesis that H2S might exert protective action via the inhibition of epigenetic histone acetylation. The results showed that elevated oxidative stress, pro-inflammatory cytokines, and inflammatory mediators were observed in this triatom of PD rats compared to controls. However, H2S exposure reversed these alterations with reduced HTC activity. Further, PD rats treated with an HTC inhibitor showed a dramatic upsurge in the level of tyrosine hydroxylase with a decreased level of glial fibrillary acidic protein, synacline, tumor necrosis factor, and other cytokines. Therefore, the study suggests that H2S exerts protection via inhibition of HGC. This article was authored by Yang Sun, Dai Li, Yuchang Su, and others. We are article.tv, links in the description below.