Improved model and visualization: patient-specific simulation of ductal carcinoma in situ (DCIS)




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Published on Aug 1, 2012

Ductal carcinoma in situ (DCIS) is a significant precursor to invasive breast cancer, which is largely detected as calcifications in mammograms. In Macklin et al. 2012 (http://www.mathcancer.org/Publication...), we introduced an agent-based model that can be calibrated to individual patient pathology. An animation can be found here: http://www.youtube.com/watch?v=b_GVnZ...

This is a test of a few model improvements:

1) Water flow in and out of the cells is improved.
2) Solids are synthesized during the cell cycle.
3) Solids are degraded during apoptosis and necrosis
4) A more physical model of calcification is included.
5) These are being calibrated to in vitro experiments at the Center for Applied Molecular Medicine.
6) The calibration has been improved to better match patient Ki-67 data.

The model refinements allow new visualizations:

1) We can perform virtual hematoxylin and eosin staining based upon the nuclear and cytoplasmic composition.
2) We can perform virtual transmitted light microscopy on the simulated H&E stains.
3) The result is this movie.

Things to look for:
1) Shrinking apoptotic cells in the viable rim.
2) Swelling oncotic (early necrotic) cells at the edge of the necrotic core
3) Increasing pyknosis (nuclear degradation) and calcification (shade of purple) towards the center of the necrotic core.

Please see MathCancer (http://MathCancer.org) for more updates! :-)


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