 Abstract photoacoustic computed tomography, PACT, is a hybrid imaging modality combining optical excitation and acoustic detection techniques. It provides high-resolution deep tissue images based on the deep penetration of light, the anisotropy of light absorption in objects, and the photoacoustic effect. This makes PACT a promising tool for biomedical sample imaging. Recent developments have seen PACT systems being used in a variety of applications, including preclinical animal imaging and human organ-slash-body-part imaging. These studies have demonstrated the potential of PACT as a powerful tool for biomedical imaging. Future developments should focus on improving the accuracy of PACT imaging by developing more sophisticated algorithms and exogenous contrast agents. This article was authored by Yin Rigu, Yuan Yuan Sun, Xiao Wang, and others.