 Evidence-based approaches were used to make recommendations for vaccination against vaccine preventable diseases for hip-infected and hip-exposed individuals, but with limited substanciation. A systematic review and meta-analysis of randomized controlled trials, RCTs, cohort and case control studies was conducted to assess the efficacy and effectiveness of vaccines in hip-infected and hip-exposed children as outcomes. The study found that 9-valent pneumococcal conjugate vaccine, PCV9, had an efficacy of 32% in hip-infected children and 78% among hip-uninfected children, while the vaccine effectiveness of bacillus calmetgeran vaccine in preventing tuberculosis in hip-infected children was zero compared to 59% protection in hip-unexposed children. The study also revealed that hip-uninfected children have better protection against invasive hemophilus influenzae type B disease than the hip-infected children, and effectiveness studies of rotavirus vaccines show that hip-exposed uninfected children have similar protection against rotavirus gastroenteritis compared to non-exposed children. The study highlights a death of efficacy and effectiveness studies among hip-infected and exposed children, with the overall quality of observational studies being very low and little confidence in the effect estimate. However, the overall quality of evidence for RCT outcomes was mainly high.