 Magnetite nanoparticles FE-304 are highly promising materials for medical applications due to their ability to carry drugs or enzymes. To reduce the saturation magnetization of these particles, they can be incorporated into mesoporous materials. Additionally, direct synthesis of mesoporous structures has been achieved through coprecipitation reactions at room temperature. These reactions involve the use of various bases, such as NaOH, KOH, or C2H5, for NOH, to produce magnetite nanoparticles with varying degrees of agglomeration. This agglomeration is believed to be responsible for the formation of mesoporous structures, which are influenced by the pH, the nature of the base used, the rate of addition of the base, and the drying method. This article was authored by Maria Cristina Muscalo, Yongbing Pei, and Terry A. Ring.