 This study investigated the role of iron deposition in subcortical nuclei in migranias compared to healthy controls. The results showed that migranias have increased iron deposition in the putamen, chordate, and nucleus accumbens, NAC. Additionally, migranias with chronic migraine, CM, had a significantly higher volume of iron deposits compared to those with episodic migraine, EM. Furthermore, higher iron deposition in NAC was found to be associated with disease progression, higher headache impact test scores, and poor sleep quality. This suggests that iron deposition in NAC may serve as a biomarker for migraine chronicity and migraine-related dysfunction. This article was authored by Xiao Pei Xu, Meng Ting Zhu, Xiao Wu, and others.