 This study investigated the protective effect of Levangela aficinalis L-extract LOE against cyclophosphamide, CP, induced nephrotoxicity in mice. The results showed that LOE significantly reduced the levels of malondialdehyde, MDA, creatinine, and blood urea nitrogen, BUN, as well as increasing the levels of glutathione, GSH, catalase, cat, and superoxide dismutase, SOD, in mice treated with CP. Histologically, LOE prevented the damage caused by CP to the kidneys. These findings suggest that LOE may be used as a potential therapeutic agent for CP-induced nephrotoxicity. This article was authored by Ali Sadiqui, Mojtaba Calantur, Sharzid Molavenia, and others.