 So, this is a report out on the systems biology breakout group. Give me one moment just to get to a part of my notes. The thing that I want to start off with in systems biology was really sort of appreciating that there's a lot of definitions about what systems biology is. I think a general agreed upon set of components is you need to generate data, integrate data across scales, make models, simulate outcomes, predict phenotypes, use those to develop hypotheses which hopefully then can be tested by a variety of means. So when it comes to our discussion, again lots of notes, please take a look at what's online. Some of the highlights that I want to walk through is first and foremost some of the questions, biological questions that came up that could be answered by systems biology. And the first one was really like trying to understand how the structure of gene and regulatory networks change or remain stable between species and over evolutionary time. Do different organisms and their gene networks respond similarly or differently in terms of perturbations to external stimuli? And then ultimately how can we modify these networks in order to have new or possibly different kind of outcomes in the world of synthetic biology? The group identified lots and lots and lots of outstanding needs. I'm just going to summarize a couple of the high level ones which resonate of course across the different groups. One of them of course is more referenced data sets. This includes high quality genomes, encode or modern code like data sets and cell atlases across multiple species. There is an appreciation that data integration and interoperability across scales and across organisms and communities is still difficult and we have a lot of improvement that we can make there. There's opportunities of course in the field of machine learning and the big data sets that we are required to train them both in terms of how ML can be used for data integration as well as for making predictions and that we do need good reference data for both developing new models, training them and then of course testing them. Another thing that we need of course are better ways to manipulate organisms at the gene level and specifically branching out to additional non-standard model organisms. It would be great to be able to crisper everything today as well as having better DNA synthesis and transformation technologies but we do need to think carefully about the species we want to manipulate very much in the same way as which ones we want reference genomes for and how do we sample that and how do we do that together as a community. In terms of a couple of the two most important things or a couple of the most important things that we might think about investing in, it really comes down to that for sense of biology, the identification and characterization of gene networks across life and really to be able to identify these conserved broad patterns of network architecture and how that changes as we take a look at specific clades of organisms or even down to an individual organism. That will give us a lot of insight into how these organisms are evolving and responding to changing environments. Like other groups we appreciate that a lot of these answers don't reside within the biological community and we need to continue to foster interdisciplinary collaborations with other groups in engineering, computer science, mathematics as well as additional opportunities to do co-training so we're developing new scientists at the intersections of those fields. There's a lot of work that we have to do in terms of linking together genotypes and phenotypes especially across species or traditional groups that work together and there's opportunities there to have better data systems and databases to allow that to happen and of course linking the systems of biology to a lot of the work that's happening now in synthetic biology. And we'll stop.