 This study has identified a long, non-coding RNA, LNCRNA, called DDIT4S1 that is highly expressed in triple negative breast cancer, TNBC. It was found that DDIT4S1 induces autophagy through its interactions with the RNA-binding protein AUF1, resulting in increased resistance to chemotherapy drugs. Additionally, the researchers developed a novel drug delivery system that combines DDIT4S1, CERNA, and PACLA-TACCEL, which can increase the efficacy of chemotherapy for TNBC patients. This article was authored by Ting Jiang, Jiao Jiao Xu, Shirlang Jiang, and others.