 Cyclic AMP camp is a ubiquitous second messenger that transduces signals from cellular receptors to downstream effectors. Mycobacterium tuberculosis MTB devotes a considerable amount of coding capacity to produce, sense, and degrade camp. Despite this fact, our understanding of how camp regulates MTB physiology remains limited. This article was authored by Andrew I-Wong, Tiago Bates, Kyle A. Plank, and others.