 Good morning Welcome to the first scientific symposia for TCGA. Where's Elaine Elaine? There's my Partner in crime We like to welcome you to this first meeting and I'm Just want to give a tool on I was giving 15 minutes So we delayed it at the beginning by 10. So now I have four minutes to do the opening which is about right When we thought about when TCGA as a community thought about this symposia It was really motivated by Matthew Myleson who brought up the point that there are so much science going on that Really didn't get the chance to be presented even within the consortium within within the network much less to the public and that The momentum of TCGA is such that it really is time to showcase What we have generated what we have learned from it and talk about what we can do with that data in the broader community And so the idea of this open and symposia, which hopefully will happen every year was formed and Elaine and I got the Honor of putting this first one together and What we wanted to do in this symposia is to highlight the science that's being done within the network but importantly to bring together the community who is number one using the data and and using it to to develop new method using it to understand new science and and to translate that to clinical Application, which is our ultimate goal to impact on the patient cares and improve survival We wanted this to be the venue where the community Within and outside of TCGA can come together and really show us how the TCGA impact can be realized so To to get us started It's a great honor to have Eric Lander as our first opening keynote speakers for our symposia Eric Lander really does not need introductions He he is the founding director of the bro Institute And the director of his genome biology program He has been one of the principal leaders in the human genome project and certainly in TCGA as well as in the international effort ICGC He has received numerous Awards and I'm not going to list them Except to mention that most recently he has been appointed by President Obama as the co-chair of the President's Council of advisors on science and technology Eric is a professor of biology MIT and the professor of system biology at Harvard Medical School He earned his BA in mathematics from Princeton in 1978 and his PhD in mathematics from Oxford in 1991 1981 as the Rose Scarlett and in 1990 he founded the Whitehead Institute MIT Center for genome Center, which eventually became the bro Institute in 2003 without further ado It's my honor to introduce Eric who's going to tell us about the challenges ahead