 The article reviews how SARS-CoV-2 attaches to host cells through various receptors, it's spike protein undergoes conformational transition with the help of proteases, ongoing experimental studies and clinical trials target host pathogen interaction to suppress viral attachment and block fusion core formation. It also discusses the need for broad-spectrum drugs or vaccines to prevent and control COVID-19 in the future due to rapidly emerging variants. This article was authored by Qianqian Zhong, Ro Xiong, Qianqian Hu and others.