 MYCN amplification leads to global suppression of circular RNA, circRNA, production in neuroblastoma, a type of childhood cancer. This suppression is dependent on the DHX9-RNA helicus, which is also involved in the same process in meduloblastoma, another type of pediatric cancer. Additionally, 25 circRNAs are found to be upregulated in neuroblastoma, including circAID1a, which is transcribed from the arid1a tumor suppressor gene and interacts with the KHSRP-RNA binding protein to promote cell growth and survival. These findings suggest that MYCN may play a role in regulating circRNA expression in cancer, and that circRNAs may contribute to the development of neuroblastoma. This article was authored by Stefan Fuchs, Clara Dansman, Philippos Cleronomos, and others.