 This study found that senile decoction can alleviate gout arthritis symptoms by regulating gut microbiota. The decoction restored the abundance of phylum proteobacteria and genus helicobacter in the gut microbiota of gout arthritis mice which was not seen after allopurinol treatment. Additionally, senile decoction had a greater impact on gut microbiota than allopurinol, suggesting that the decoction may be more effective at treating gout arthritis. This article was authored by Xiaoying Lin, Mingzhu Wang, Zhixin He and others.