 This systematic review compares COVID-19 vaccine uptake in the U.S. and investigates predictors of hesitancy and acceptance among different groups. The study found that increased unwillingness towards the vaccine and being black-slash African-American were correlated with low vaccine uptake. Sex, race, age, education level, and income status also determined vaccine uptake. Two studies showed an increase in vaccine acceptance between 2020 and 2021. The results confirm that hesitancy exists in the U.S. population, particularly among black-slash African-Americans, pregnant or breastfeeding women, and low in the male sex. Regulatory bodies should acknowledge these statistics and revise vaccine delivery plans to mitigate the burden of unvaccinated individuals. This article was authored by Farah Yasmin, Hala Najib, Abdul Maud, and others.