 Epigenin is a natural compound found in many plants and fruits, with potent anti-inflammatory, antioxidant, antimicrobial, and anti-cancer properties. It has been shown to reduce inflammation, prevent oxidative stress, and kill bacteria and viruses. Additionally, it has been observed to slow down the growth of tumours and promote apoptosis, cell death, in cancerous cells. Furthermore, epigenin has been found to target several key signalling pathways involved in cancer development, such as the PI3KAKT, MAPKERK, JAKSTAT, NFB, and WNTKNIN pathways. This review provides an overview of the latest research into the anti-cancer effects of epigenin, as well as its potential applications as an adjunctive treatment for cancer patients. This article was authored by Xiaohui Yang, Miaoqi, Pengfei Li, and others.