 This study examined 51 patients with low-grade appendiceal mucinous neoplasm, LAMN, from 2013 to 2018, comparing serum tumor markers between two groups of patients with and without the potential for a malignant condition. The results showed significant differences in CA125, CA19-9, and CA levels between the two groups, and that patients with normal CEA had longer disease-free survival time than those with abnormal CEA. Additionally, CA19-9 was found to have a significant association with disease-free survival in the univariate analysis. The study highlights the importance of serum tumor markers, surgical procedure, and pathology in predicting the prognosis of LAMN. This article was authored by Jiang Chun-sao, Pei Heng Li, and Wei Liu.