 This study found that the average cost of a conventional operating room or is 9 euros and 45 cents per minute while the average cost of a hybrid or is 19 euros and 88 cents per minute. The main factors driving these costs are total inventory costs, total construction costs, utilization rate, and total personnel costs. This information can help hospitals make informed decisions about adopting hybrid ORs and optimizing their use. This article was authored by Siegel Patel, Melanie Lindenburg, Maroesca M. Rovers, and others.