 Anthropogenic transmission of SARS-CoV-2 to pet cats highlights the importance of monitoring fields for exposure to circulating variants. We tested cats in the United Kingdom for SARS-CoV-2 antibodies. Cerro prevalence peaked during September 2021 to February 2022. The variant-specific response in cats trailed circulating variants in humans, indicating multiple human-to-cat transmissions over a prolonged period. This article was authored by Grace B. Tyson, Sarah Jones, Nicola Logan, and others.