 This study investigates the use of patient-reported outcome measures, PROMs, and patient-reported experience measures, PREMs, in the evaluation of telemedicine, covering all application types and medical purposes. The results show that PROMs are more frequently assessed than PREMs, with health-related quality of life being the most commonly measured outcome domain. The study also found that the use of PROMs and PREMs has increased over time, particularly in high-evidence studies. However, health literacy is a precondition for using the application adequately has rarely been reported. Further efforts should be pursued to standardize PROM and PREM collection in evaluation studies of telemedicine. This article was authored by Andreas Knapp, Lorenz Horst, Stefan Hager, and others.