 This paper examines the weather, climate, and climate variability of the Andes mountain range in South America. It explains how the topography of the Andes creates unique weather patterns, such as the disruption of the large-scale circulation due to its long meridional extent. The paper also discusses the impact of the El Niño Southern Oscillation, ENSO, phenomenon on the temperature and precipitation regimes along the Andes. This article was authored by R. D. Garode.