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How does DNA fold? The loop extrusion model

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Published on Oct 19, 2015

The human genome is two meters long but fits inside the microscopic nucleus of a cell. How does it do this? Our work suggests that the genome forms loops and domains through a process called extrusion!

For more information, see

"Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes." Sanborn and Rao et al., PNAS 2015.
http://www.pnas.org/content/early/201...

Directed by Adrian Sanborn and Erez Aiden
Animated by Najeeb Tarazi
Narrated by Adrian Sanborn

www.aidenlab.org
www.adriansanborn.com
www.suhasrao.com

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