 Parkinson's disease is a disease of dopamine deficiency in the brain. You can't just have people take dopamine because it can't pass through the blood-brain barrier, but you can give people a dopamine precursor called levodopa, or L-dopa, which can get up into the brain and be turned into dopamine. However, with prolonged treatment, patients start to show a reduced response to levodopa. After five years of levodopa treatment, the benefits start wearing off before the next dose or don't completely contain symptoms in a substantial proportion of patients and represents a major source of disability and significantly impairs quality of life. Therefore, maximizing the therapeutic efficiency of levodopa is an important goal, and that's where protein-restricted diets come in. Wait, what does protein have to do with Parkinson's? Minimino acids in proteins have been proven to impair the therapeutic effect of levodopa by reducing its absorption and influx into the brain because they use the same transporters so can crowd each other out. Here's a before-and-after PET scan showing levodopa activity in the brain before and after protein loading. That's why protein-restricted diets can improve the efficacy of levodopa. There are three ways to do that. In overall, low protein diet, a so-called protein redistribution diet or a combination of the two. As a dietary strategy, a low protein diet, it's nice because it's not only effective, but also simple to understand and follow. And by low protein, we're just talking about sticking to the recommended amount of protein, 0.8 grams per kilogram of body weight, as I've covered before. Most people are eating excess protein and suffering because of it. 0.8 grams per kilogram is equivalent to about 0.36 grams per pound. So you take your weight in pounds, multiply times 0.36, and get how many grams in protein you should eat in a day. So if you're 140 pounds, you should eat about 50 grams of protein a day. The positive effect of limiting dietary protein can be noticed within one week, but protein in patients no longer responding to the manipulation of levodopa's medication schedule or to other anti-Parkinson drugs. Protein redistribution diets have been investigated most thoroughly and have been confirmed to be effective with a remarkable 60% to 100% response rate. We know about the deleterious influence of dietary protein and the benefit of a low protein diet. However, it's not only the total amount of daily protein, but also how it's distributed over the day. If we eat only protein-rich foods at night, staying under a total of 10 grams a day for breakfast and lunch, then we eliminate the amino acid surges during the day, and who cares if they surge after we go to bed? Parkinson's is a movement disorder. And so if the drugs are not going to work, then it might as well be when you're sleeping. Fiber is another way to get levodopa to work better. Significant improvements in L-dopa blood levels and Parkinson's symptoms starting as early as 30 to 60 minutes after eating a diet rich in insoluble fiber, like the kind found concentrated in whole grains. Well, if fiber helps, then how about a plant-based diet for the management of Parkinson's disease? You don't know until you put it to the test. They looked at a normal protein amount redistributed plant-based diet and Parkinson's patients saw significant improvement in symptoms and performance, making it a convenient way to conjugate the positive effects of non-excess protein intake and a high fiber intake without limiting total food amount. Planting such a diet is rather simple, centering around unprocessed plant foods, but reserving protein-rich plants, like beans, split peas, chickpeas, lentils, and peanuts, to the evening meal. And voila! The clinical improvement hit all the major motor signs, the rigidity, the tremor, and the slowness of movement. The things that really matter to Parkinson's patients, in particular the tremor, the shaking, which often does not respond to drugs, but was highly positively affected by the plant-based diet. So, plants may be preferable for Parkinson's, but you don't know how well it'll work for you until you give it a try.