 Nanoarchitectonics concept is essential to bridge the gaps between biology and materials chemistry. Based on this fundamental principle, this review article provides poor engineered nanoarchitectonics for cancer therapy by integrating basic descriptions and exemplifying therapy applications. This review paper briefly summarizes poor engineered nanoarchitectonics basics according to classification based on material porosity and composition. We discuss how to design mesoporous material and highlight the appealing points of the progress in the clinical translation of mesoporous materials for cancer treatment. Nanoarchitectonics could be an important key concept for future advanced life technologies as well as currently required cancer therapy. This article was authored by Linowati Satrisno and Katsuhiko Origa.