 This study suggests that ANGPT-2 plays a key role in hypertrophic scarring by regulating autophagy and the PI-3-K slash ACT slash M2R signaling pathway. Knockdown of ANGPT-2 inhibits cell proliferation, migration, and extracellular matrix accumulation in hypertrophic scar fibroblasts, suggesting that ANGPT-2 may be a promising therapeutic target for hypertrophic scars. This article was authored by Hongxin Chen, Kai-su, Chao Sun, and others.