 Carboponams are a class of antimicrobial agents reserved for infections caused by multi-drug-resistant microorganisms. The emergence of carboponam resistance has become a serious public health threat. This type of antimicrobial resistance is spreading at an alarming rate, resulting in major outbreaks and treatment failure of community-acquired and nosocomial infections caused by the clinically relevant carboponam-producing enterobactericea or carboponam-resistant enterobactericea. This review is focused on carboponam resistance, including mechanisms of resistance, history and epidemiology, phenotypic and genotypic detection in the clinically relevant bacterial pathogens and the possible treatment options available. This article was authored by Anay Elshami and Khaled Maboshnab.