 Skin wound healing is a complex process that involves the interaction of several cells, growth factors, and cytokines, with ongoing studies aiming to develop more effective wound therapies for reducing inpatient costs, providing long-term relief, and effective scar healing. The review focuses on progress in wound medication, complications related to the healing process, advanced treatment strategies for skin regeneration, and experimental techniques for cellular engineering and skin tissue engineering. Emerging skin regeneration techniques using scaffolds activated with growth factors, bioactive molecules, and genetically modified cells are being explored to overcome limitations and implement personalized therapy design. This article was authored by Erika Maria Todely, Rasella Dorati, Ida Jenta, and others.