 Abstract Guillen-Barr syndrome, GBS, is a rare autoimmune disease that often manifests as a post-viral complication. However, its association with severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, is unclear. We present a rare case of GBS secondary to COVID-19 infection complicated by rapidly progressive sensorimotor deterioration resistant to plasma exchange therapy. This article was authored by Dina H. Tran, Dalwinder Basra, Zahid Bilgrami, and others.