 Drought stress is a major environmental factor that affects plant productivity and distribution. It causes morphological, physiological, and biochemical changes in plants to reduce water loss through transpiration and increase water use efficiency. Stomate closure is one of the first responses to drought, which leads to adjustments in photosynthesis and defense mechanisms against stress. Techniques such as aquaporin synthesis and osmolite accumulation can be used to increase tolerance to drought and crop species. This review highlights the impact of drought on plant features and mechanisms of tolerance that could be exploited for increased survival under limited water availability. Additionally, applicative strategies are discussed to help plants counteract unfavorable drought periods. This article was authored by Dirty Kapoor, Savita Bardwaj, Marco Landi, and others.