 Good morning, everyone. I am Dr. Nishita Goyal from Shidama Chandra Institute of Higher Education and Research, and today I'll be presenting on the topic of predicting the association between PET CT SCV max value and prognostic markers in pre treated primary breast cancers under the guidance of Dr. The aim of my study is to assess the correlation between SCV max of pre treated primary breast cancers with prognostic markers like IHC receptor status and metastasis nodal as well as distant. It was an observational study done at the department of radio diagnosis in our institute from March 2017 to April 2021 into 28 patients were referred for whole body PET CT imaging. The exclusion criteria were for the patients who are undergone primary breast cancer evaluation with PET CT at our department and had complete HP IHC panel data. Exclusion criteria were the patients who obtained any previous treatment before undergoing PET CT investigation or did not have required HP or IHC data. The ER negative patients were 90 out of 228 with a higher mean SCV max value of 9.5 which was found to be significant. The PR negative patients were 180 which had again a higher mean SCV uptake of 9.2 and was found to be significant. The her to new negative and positive patients were having a similar mean SCV max uptake of 7.1 and 7.7 which was not found to be significant. The her to new enriched variant patients were 38 in number which were having a higher mean SCV max uptake of 8.7 and was found to be significant. The triple negative breast cancer patients were 49 in number and had a higher mean SCV max uptake of around 10 which was found to be significant. The coming to the proliferation index of cut off with cut off less than equal to 15% and more than 15% patients with higher care 67 index were around 186 in number with a higher mean SCV max uptake of 7.7 which was found to be significant. The axillary nodal spread was seen in 172 patients with a higher median SCV max uptake of 8.3 again found to be significant. Similar results were seen in patients with distal metastasis, which were 68 in number having a median SCV max uptake of 8.7 and found to be significant. Coming to the discussion. The correlation between high mean SCV max uptake value and negative estrogen receptor status was found to be significant by these 10 studies. However, three studies did not find any significant association between the two factors for correlation between high mean SCV max uptake value and negative estrogen receptor status. It was found to be significant by the six studies mentioned here. However, four studies did not find any significant association to note in studies conducted by Zung et al and Hibushi et al, they found it difficult to differentiate between high mean SCV max uptake value. These done pect city imaging SCV max uptake values correlation between mean SCV max uptake value and increase her to new receptor state expression status was found to be significant by these seven studies, however, 10 studies showed no significant association between the two factors correlation between the high mean SCV max uptake value and ERPR negative her to new positive, which is the her to new enriched variant was found to be significant these these five mentioned studies. However, four studies did not find any significant association between the two correlation between high mean SCV max uptake value of TNBC versus non triple negative breast cancer variance was found to be significant in nine of these mentioned studies, the non triple negative breast cancers were found to have lower SCV max uptake as compared to the triple negative breast cancer molecular variant correlation between the high mean SCV max uptake value and K67 proliferation index was found to be significant in these 10 studies higher case it's a seven index was invariably been seen to have a poor prognosis and an added need for adjuvant therapy correlation between the high median median SCV max uptake value and auxiliary nodal spread was found to be significant in this text mentioned studies. However, these three studies did not find any significant association between the two correlation between the high median SCV max uptake value understand metastatic spread was found to be no having no association between the three studies mentioned here. However, no literature shows any significant positive correlation between the two variants. This is a summary of comparison in our study as compared to the others. In this graph, we can see the studies that are marked in red show that there are no the conducted study did not find any significant association between the mentioned factors, mostly the studies that have been conducted as per as in congruent with our study did not find any significant association between the isolated her to a new receptor stated. However, study conducted by Dr. Udy et al. found it significant association between this factor. Another study conducted by Ed McGlue et al did not find any significant association between the PR negative status and higher mean SCV uptake value. However, it was found significant association in our study. The study conducted by Buck et al. They did not find any significant association for ER PR or how to negative status, and a study conducted by Udy et al they did not find any significant association for actually live note. However, no data in literature has been shown to find a find any SCV uptake value correlation with the distant metastasis. In conclusion, we can say that luminal a will have a mean SCV max uptake value of around 7.1 with a key 67 proliferation index around 4.1 mean SCV update for luminal be the mean SCV uptake will be around 7.1 with a key 67 around 7.7. With a new new end rich kind of a variant, the mean SCV max uptake will be 8.7 with key 67 more than 15 which is around 7.7 the triple negative best cancers will have the maximum mean SCV max uptake up around 10.1. The lesion with higher SCV uptake has been found to be associated with nodal metastasis. No supporting literature was available for lesions with higher SCV uptake having distant metastasis. However, we found significant association between the two variables. These are the representative case the case one, the patient presented with a left breast, suspicious left breast lump and underwent PET CT examination at our department, the SCV max value was found to be around 3.9. Later undergoing biopsy the patient, it was reported as luminal a type of breast cancer case to in which the patient had a left breast lump right breast lump I'm sorry. The mean SCV max uptake was around 6.5 on biopsy it was reported to be as luminal type B. This case three has a bilateral breast lump on both the breast lump in the right side it was SCV max value of 9.0 in the left it was around 8.9. On biopsy both the lesions were later reported as her to new enriched. This case four is the patient with the left breast lump with the SCV max value of more than 10, and on biopsy it was reported to be as triple negative molecular supply. In conclusion, I would like to say that a significantly higher SCV max was seen in tumors with EIPR negative status triple negative her to new enriched status high K67 axillary nodal spread and distant meds. However, no significant correlation was seen in isolated her to new status. According to our study based on SCV max uptake it is difficult to differentiate between luminal a and b sub type but we can differentiate among the luminal her to new enriched and triple negative breast cancers. These are my references. Thank you.