 SEVI is a protein fragment derived from semen that contributes to the spread of HIV infection by facilitating the virus's ability to attach to target cells. This protein fragment consists of two smaller fragments, PAP248-286 and PAP85-120, which work together to enhance the virus's ability to infect cells. Molecular modeling and metodynamics were used to study how these fragments form into amyloid fibrils, which are long, thin structures composed of proteins that can cause damage to cells. These fibrils were found to have a horseshoe shape, with two bends in the middle of the structure. This shape is similar to what is seen in other amyloid fibrils, suggesting that this may be the mechanism for how they form. This article was authored by A.O. Nikitina, A.R. Yomitov, A.M. Kosova, and others.