 Glucorizoradix GR, a traditional Korean herbal medicine, has been shown to have beneficial effects in a mouse model of ulcerative colitis. GR administration resulted in reduced inflammation, weight loss, and microscopic damage to colon tissues which was associated with down-regulation of pro-inflammatory cytokine production and up-regulation of anti-inflammatory cytokines. Furthermore, GR treatment led to decreased phosphorylation of nuclear factor capillite chain enhancer of activated B cells, NFB, P65 and inhibitor of Kappa B alpha, IB. These results suggest that GR may be upon a syntherapeutic agent for ulcerative colitis. This article was authored by Yongdiokjaon, Kiksebang, Minikyung Shin, and others.