 The article discusses the importance of protecting infants against influenza and how maternal immunization is an attractive possibility to overcome the problem that available vaccines cannot be used in the first six months of age, a period of life characterized by the highest risk of influenza-related complications. However, despite maternal immunization, a number of children have no protective antibody levels at birth and in the majority of children with antibody protection, it is limited to the first eight weeks of the postnatal period. Additionally, data on LAIV effectiveness in the pediatric population must be clarified because this vaccine can significantly improve vaccination coverage in children. This article was authored by Nicola Princeipi and Susanna Esposito.