 Human personality can be divided into three levels, individual traits, temperament profiles, and character profiles. These levels are further connected by a temperament character network, which regulates learning and well-being. Negative effect and life satisfaction depend on the temperament character network for intentional self-control, while positive effect depends on the temperament character network for self-awareness. This research provides insight into how personality influences well-being and suggests that understanding these connections could lead to better interventions for improving mental health. This article was authored by Paolo A.S. Morera, Richard A. Inman, and C. Robert Cloninger.