 Okay, thank you all for and thanks. Thank you the foundation for inviting us all to speak and present our Really really important studies. I think we've heard wonderful project so far So our work is on epilepsy and most of you know that epilepsy does affect Unfortunately one to three percent of the population and that is mostly children, but also the elderly We do have a wide array of drugs available to treat epilepsy however There are 30 to 40 or 45 percent of patients who do not find seizure control with these drugs And that means that they are constantly at a risk of a seizure which can result in injury or even death So what can we do about this? my lab has looked into energy metabolism in the into the in the brain for a long time and We and others have found that There is an impairment in glucose uptake in the epileptic brain and also the epileptic brain has trouble Metabolizing this glucose by the Krebs cycle so that less energy is produced So with less ATP produced in the brain We're obviously short of energy to maintain neuronal membrane Potentials and to maintain normal normal signaling and this can result in seizures Now what can you do about it for a while? We have looked at alternative fuels to provide the brain in epilepsy With fuels alternative to glucose and those were medium-chain triglycerides or ketones Now that is effective. However, patients have to change their diet drastically with these treatments So now we're looking at improving glucose energy metabolism but trying to improve the Entry of glucose derived carbons into the TCA cycle or the Krebs cycle to make more energy and This will hopefully result in an easier treatment Appeal which has less side effects than our drugs that all sedate the brain. So I thank the foundation Hardily Because this project would not have been able to continue without the funding