 This study evaluates changes in topical antibiotic prescribing trends for acne using national ambulatory medical care survey data from 1993 to 2012, showing a decline in erythromycin use and an increase in clindamycin use. The study also found that publication frequency of erythromycin and clindamycin resistance increased over time, with yearly publications consistently exceeding 100 papers for both antibiotics in the respective years of 1983 and 2003. The findings suggest that topical erythromycin use for acne has essentially ceased, while clindamycin use is increasing, despite current recommendations discouraging monotherapy with topical antibiotics. This article was authored by Brette Austin and Alan B Fleischer.