 I am honoured and thrilled to be a recipient of a Brain Foundation research grant for 2023. With this grant, I will be performing a cutting-edge bioinformatics experiment called single nuclei transcriptomics. In this experiment, I will compare the changes to gene expression that occur due to carrying genetic mutations that are causative for two different types of dementia. The first type is Alzheimer's disease, the most common form of dementia. The second is San Felipo syndrome, which is a rare currently uncurable type of childhood dementia. I will achieve this by using my zebrafish models of each of these diseases, and I will look at the single cell level, what are the changes that are occurring. If I can identify commonalities between these diseases, this gives us the opportunity to develop therapies that could be beneficial for both types of dementia. I'd like to thank the Brain Foundation for their very generous support in getting this project off the ground. Thank you very much.