 This paper examines the effect of different types of sugars and fats on body composition and metabolic health. It found that a combination of fructose and glucose was more obesogenic and metabolically adverse than when either monosaccharide was consumed alone. However, with increasing dietary fat content, the effects of dietary sugar composition became less pronounced. Additionally, higher fat intake was more harmful for glucose tolerance and insulin sensitivity regardless of the sugar mix consumed. These results suggest that both dietary fat and sugars can lead to adverse metabolic outcomes, depending on the dietary context. This article was authored by Gibranay Wally, Doon N.I., Harrison J.W. Facey, and others.